(1S,4R)-(−)-4-(Fmoc-amino)-2-cyclopentene-1-carboxylic acid
(1S,4R)-(−)-4-(Fmoc-amino)-2-cyclopentene-1-carboxylic acid (CAS 220497-64-3) is an unnatural amino acid derivative with a molecular weight of 349.38 g/mol. This compound features a protected amine and a carboxylic acid functionality on a cyclopentene ring, making it a valuable building block in organic synthesis. It is primarily utilised in peptide chemistry and chemical biology research for constructing modified peptides and complex molecular architectures.
- Synonyms
- C21H19NO4

Peptide Synthesis
This Fmoc-protected amino acid serves as a building block for incorporating unnatural cyclic amino acid residues into peptide sequences. Its unique structure can introduce conformational constraints or novel functionalities into peptides.
Chemical Biology
Used in the development of modified peptides or peptidomimetics for studying biological processes. The cyclopentene moiety offers a distinct scaffold for probing protein-ligand interactions or developing new therapeutic agents.
Organic Synthesis Intermediate
Serves as a versatile intermediate in the synthesis of complex organic molecules. The protected amino group and carboxylic acid allow for selective derivatization and further chemical transformations.
| Molecular weight | 349.38 |
|---|---|
| Empirical formula | C21H19NO4 |
| Assay | ≥95.0% |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1S,4R)-(−)-4-(Fmoc-amino)-2-cyclopentene-1-carboxylic acid used for?
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This compound is primarily used as a building block in peptide synthesis and chemical biology research. It is also employed as an intermediate in organic synthesis for creating complex molecules.
What is the CAS number and formula for (1S,4R)-(−)-4-(Fmoc-amino)-2-cyclopentene-1-carboxylic acid?
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The CAS number is 220497-64-3, and the empirical formula is C21H19NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥95.0%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling requirements for this chemical?
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Handling this chemical requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. The compound is classified under WGK Germany 3, indicating a high hazard to water.
How is (1S,4R)-(−)-4-(Fmoc-amino)-2-cyclopentene-1-carboxylic acid shipped and exported?
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This product is stored at 2-8°C and is available for global export. Specific shipping and handling procedures are followed to maintain product integrity during transit.
How can I request a sample or quote?
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To request a sample or a detailed quote, please contact the Tech Serve Solutions sales team through our website or by calling our main office.
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