(1S,2S)-Pseudoephedrine α-fluoroacetamide
(1S,2S)-Pseudoephedrine α-fluoroacetamide (CAS: 204323-36-4) is a chiral compound with the molecular formula C12H16FNO2 and a molecular weight of 225.26 g/mol. It serves as a valuable building block in organic synthesis, particularly in asymmetric synthesis. Its specific stereochemistry makes it useful for introducing chirality into target molecules, aiding in the development of complex organic structures and pharmaceutical intermediates. This compound is supplied by TSS with an assay of 98%.
- Synonyms
- C12H16FNO2

Chiral Auxiliary in Asymmetric Synthesis
This compound functions as a chiral auxiliary, enabling stereoselective transformations in organic chemistry. Its defined stereochemistry can direct the formation of new chiral centres with high enantiomeric excess.
Building Block for Complex Molecules
Its unique structure makes it a useful synthon for constructing complex organic molecules. It can be incorporated into larger structures to impart specific stereochemical properties.
Intermediate in Pharmaceutical Research
As a derivative of pseudoephedrine, this fluoroacetamide may find application in the synthesis of novel pharmaceutical compounds. Its chiral nature is critical for developing stereospecific drugs.
| Molecular weight | 225.26 |
|---|---|
| Empirical formula | C12H16FNO2 |
| Assay | 98% |
| Optical activity | [α]20/D +122°, c = 1 in chloroform |
| Melting point | 85-89 °C(lit.) |

Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1S,2S)-Pseudoephedrine α-fluoroacetamide used for?
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(1S,2S)-Pseudoephedrine α-fluoroacetamide is primarily used as a chiral auxiliary in asymmetric synthesis and as a building block for the construction of complex organic molecules, potentially including pharmaceutical intermediates.
What are the CAS number and formula for this compound?
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The CAS number is 204323-36-4 and the empirical formula is C12H16FNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (1S,2S)-Pseudoephedrine α-fluoroacetamide with an assay of 98%. TSS does not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should (1S,2S)-Pseudoephedrine α-fluoroacetamide be handled?
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This compound is classified as a GHS07 irritant. Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid inhalation of dust and ensure adequate ventilation. Refer to the Safety Data Sheet for comprehensive handling information.
Is this compound a controlled substance?
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The provided data does not indicate that (1S,2S)-Pseudoephedrine α-fluoroacetamide is a controlled substance.
How is this chemical packed and shipped?
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Tech Serve Solutions packs and ships chemicals according to international shipping regulations and best practices for product integrity and safety. Specific packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or sample of (1S,2S)-Pseudoephedrine α-fluoroacetamide, please contact our sales team through the TSS website or via direct inquiry, providing your specific requirements and contact details.
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