(1R,2R)-(−)-Norpseudoephedrine
(1R,2R)-(−)-Norpseudoephedrine (CAS: 37577-07-4), a chiral amino alcohol with the molecular formula C9H13NO, serves as a valuable building block in asymmetric synthesis. Its specific stereochemistry makes it particularly useful for introducing chirality in organic molecules. Commonly employed as a chiral auxiliary, it facilitates the stereoselective formation of new chiral centres, enabling the synthesis of complex enantiomerically pure compounds for various chemical and pharmaceutical research applications.
- IUPAC
- (−)-Pseudonorephedrine,(1R,2R)-2-Amino-1-phenyl-1-propanol,(R,R)-α-(1-Aminoethyl)benzenemethanol,L-(−)-Norpseudoephedrine
- Synonyms
- (−)-Pseudonorephedrine(1R,2R)-2-Amino-1-phenyl-1-propanol(R,R)-α-(1-Aminoethyl)benzenemethanolL-(−)-Norpseudoephedrine
Chiral Auxiliary in Asymmetric Synthesis
This compound functions as a chiral auxiliary, enabling stereocontrolled synthesis of target molecules. It can be covalently attached to a substrate, directing subsequent reactions to occur with high diastereoselectivity.
Building Block for Chirality
Its inherent chirality makes it an ideal starting material or intermediate for constructing complex chiral molecules. This is crucial in the synthesis of pharmaceuticals and other biologically active compounds where specific stereoisomers are required.
Synthesis of Ephedrine Derivatives
As a derivative of ephedrine, it is employed in the synthesis of related compounds and analogues. This allows for the exploration of structure-activity relationships in medicinal chemistry.
| Molecular weight | 151.21 |
|---|---|
| Empirical formula | C9H13NO |
| Assay | ≥98.0% (NT) |
| Optical activity | [α]/D -34.0±2.0°, c = 3.5 in ethanol |
| Storage temperature | 2-8°C |
Hazard statements
- H301Toxic if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Drug Control | regulated under CDSA - not available from Canada |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1R,2R)-(−)-Norpseudoephedrine used for?
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Tech Serve Solutions supplies (1R,2R)-(−)-Norpseudoephedrine primarily as a chiral building block and auxiliary in asymmetric synthesis for chemical and pharmaceutical research and development.
What is the CAS number and formula for (1R,2R)-(−)-Norpseudoephedrine?
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The CAS number is 37577-07-4 and the empirical formula is C9H13NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (1R,2R)-(−)-Norpseudoephedrine with an assay of ≥98.0% (NT). We do not represent this product as USP, BP, or EP grade.
How should (1R,2R)-(−)-Norpseudoephedrine be handled safely?
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This compound is dangerous and corrosive. Handle with appropriate personal protective equipment, including a dust mask (type N95), eyeshields, face shields, and gloves. Refer to the safety data sheet for full handling instructions.
Is (1R,2R)-(−)-Norpseudoephedrine a controlled substance?
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Yes, this compound is regulated under CDSA and is not available from Canada.
How can I request a sample or quote for (1R,2R)-(−)-Norpseudoephedrine?
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Please contact our sales team directly through our website to request a sample or a formal quotation for (1R,2R)-(−)-Norpseudoephedrine.
How is (1R,2R)-(−)-Norpseudoephedrine packaged and shipped?
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(1R,2R)-(−)-Norpseudoephedrine is shipped internationally as UN 2811, Hazard Class 6.1, Packing Group III, under strict regulatory compliance.
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