1-Methylpiperazine
1-Methylpiperazine (CAS: 109-01-3, C5H12N2) is a clear, colourless to pale yellow liquid with a molecular weight of 100.16 g/mol. This heterocyclic amine is widely employed as a versatile building block in organic synthesis, particularly in the pharmaceutical and agrochemical industries. Its reactivity makes it a valuable intermediate for the preparation of more complex molecules. Tech Serve Solutions supplies this chemical with an assay of ≥99.0% (GC).
- Synonyms
- 1-MethylpiperazineN-MethylpiperazineMethylpiperazine

Pharmaceutical Intermediate
1-Methylpiperazine serves as a crucial building block in the synthesis of various pharmaceutical active ingredients (APIs). Its piperazine ring is a common structural motif in many drugs, contributing to their pharmacological activity.
Agrochemical Synthesis
This compound is utilised in the development and manufacturing of agrochemicals, including herbicides, insecticides, and fungicides. It helps in the construction of molecules designed for crop protection.
Organic Synthesis Reagent
As a heterocyclic building block, 1-Methylpiperazine is employed in diverse organic synthesis pathways. Its nucleophilic nitrogen atoms allow for various chemical transformations, facilitating the creation of novel chemical entities.
Catalysis Research
In research settings, derivatives of 1-Methylpiperazine may be explored for their potential catalytic properties in various chemical reactions.
| Molecular weight | 100.16 |
|---|---|
| Empirical formula | C5H12N2 |
| Assay | ≥99.0% (GC) |
| Boiling point | 138 °C(lit.) |
| Density | 0.903 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.466(lit.)n20/D 1.466 |
| Vapour density | 3.5 (vs air) |



Hazard statements
- H226Flammable liquid and vapour
- H312Harmful in contact with skin
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 39 °C / 102.2 °F |
| Transport (UN / ADR) | UN 2734 8/PG 2 |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-20/21-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Methylpiperazine used for?
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1-Methylpiperazine is primarily used as a building block in organic synthesis, particularly for the development of pharmaceuticals and agrochemicals. It is also employed as a versatile intermediate in chemical synthesis.
What is the CAS number and formula for 1-Methylpiperazine?
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The CAS number for 1-Methylpiperazine is 109-01-3, and its empirical formula is C5H12N2.
What grade and purity does Tech Serve Solutions supply for 1-Methylpiperazine?
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Tech Serve Solutions supplies 1-Methylpiperazine with an assay of ≥99.0% (GC). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 1-Methylpiperazine be handled safely?
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1-Methylpiperazine is a dangerous substance. It is flammable (Flash Point: 39 °C) and causes severe skin burns and eye damage (H314). It is also harmful if swallowed or inhaled (H331, H312). Always use appropriate personal protective equipment, including gloves, goggles, and a suitable respirator, and handle in a well-ventilated area. Consult the Safety Data Sheet (SDS) for detailed handling procedures.
Is 1-Methylpiperazine a controlled substance?
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Based on the provided data, there is no indication that 1-Methylpiperazine (CAS: 109-01-3) is a controlled substance in major jurisdictions. However, users should always verify local regulations.
How is 1-Methylpiperazine packed and shipped?
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1-Methylpiperazine is shipped according to its hazard classification (UN 2734, Class 8, Packing Group II). Packaging adheres to international regulations for hazardous materials to ensure safe transport and export.
How can I request a quote or sample for 1-Methylpiperazine?
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To request a quote or sample of 1-Methylpiperazine, please visit the Tech Serve Solutions website or contact our sales department directly with your specific requirements.
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