1′-Hydroxymidazolam
1′-Hydroxymidazolam (CAS 59468-90-5) is a chemical compound with the molecular formula C18H13ClFN3O and a molecular weight of 341.77 g/mol. As a known CYP3A4 metabolite of midazolam, this compound is primarily utilised in research settings for studies related to drug metabolism, cell signalling, and neuroscience. Its specific hydroxymethyl group contributes to its unique biochemical profile.
- IUPAC
- 8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine
- Synonyms
- 8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine
Drug Metabolism Studies
Utilised as a standard for identifying and quantifying the metabolic pathways of midazolam, particularly its role in CYP3A4-mediated biotransformation. This helps researchers understand drug clearance and potential drug-drug interactions.
Neuroscience Research
Investigates the pharmacological effects and receptor interactions of midazolam metabolites within the central nervous system. Useful for exploring the mechanisms of benzodiazepine action and related neurological processes.
Cell Biology and Signalling
Serves as a tool in cell-based assays to study the impact of drug metabolites on cellular functions and signalling pathways. Aids in understanding cellular responses to xenobiotics.
| Molecular weight | 341.77 |
|---|---|
| Empirical formula | C18H13ClFN3O |
| Colour | white to off-white |
| Storage temperature | 2-8°C |
| Application | CYP3A4 metabolite of midazolam. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Drug Control | regulated under CDSA - not available from Canada |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1′-Hydroxymidazolam used for?
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1′-Hydroxymidazolam is primarily used in research for studies involving drug metabolism, specifically as a CYP3A4 metabolite of midazolam. It is also applied in cell biology, cell signalling, and neuroscience research to understand the effects of drug metabolites.
What is the CAS number and chemical formula for 1′-Hydroxymidazolam?
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The CAS number for 1′-Hydroxymidazolam is 59468-90-5, and its empirical formula is C18H13ClFN3O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1′-Hydroxymidazolam as a research chemical. The specific assay and purity are detailed in the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
What are the safety considerations for handling 1′-Hydroxymidazolam?
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Handling 1′-Hydroxymidazolam requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Refer to the Safety Data Sheet (SDS) for full hazard information. It is classified with WGK Germany 3.
Is 1′-Hydroxymidazolam a controlled substance?
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Yes, 1′-Hydroxymidazolam is regulated under CDSA and is not available from Canada.
How is 1′-Hydroxymidazolam shipped and exported?
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Tech Serve Solutions, a specialist global supplier and exporter, ships and exports 1′-Hydroxymidazolam according to international regulations for chemical compounds. Storage is recommended at 2-8°C.
How can I request a quote or sample of 1′-Hydroxymidazolam?
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To request a quote or sample of 1′-Hydroxymidazolam, please contact our sales department through the website or by phone. Our team will assist you with your inquiry.
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