1-Ethylpiperidine hypophosphite
1-Ethylpiperidine hypophosphite (CAS: 145060-63-5, Formula: C7H18NO2P, MW: 179.20) is a versatile chemical reagent. This compound serves as a valuable building block in organic synthesis, particularly for constructing complex heterocyclic structures. Its applications include facilitating radical deoxygenation, enabling spiroketal synthesis via intramolecular iodoetherification, and participating in facile radical cyclization reactions. Supplied at 95% purity, it is suitable for research and chemical synthesis purposes.
- IUPAC
- 1-Ethylpiperidinium phosphinate
- Synonyms
- 1-Ethylpiperidinium phosphinate
Synthesis of Spiroketals
1-Ethylpiperidine hypophosphite is employed as a reagent in the synthesis of spiroketals through intramolecular iodoetherification reactions, contributing to the formation of complex cyclic structures.
Radical Cyclization and Rearrangement
This compound facilitates a facile radical cyclization process. Under basic conditions, this reaction can be diverted into a rearrangement-cyclization pathway, offering synthetic flexibility.
Radical Deoxygenation
It serves as an effective reagent for radical deoxygenation reactions, a useful transformation in organic synthesis for removing oxygen-containing functional groups.
Allylic H-phosphinates Synthesis
1-Ethylpiperidine hypophosphite is utilised in the synthesis of allylic H-phosphinates, expanding its utility in the preparation of organophosphorus compounds.
| Molecular weight | 179.20 |
|---|---|
| Empirical formula | C7H18NO2P |
| Assay | 95% |
| Storage temperature | 2-8°C |
| Application | Reagent for: Synthesis of spiroketals via intramolecular iodoetherification1 A facile radical cyclization diverted to a rearrangement-cyclization with base2 Radical deoxygenation3 Synthesis of allylic H-phosphinates4 |
| Melting point | 40-43 °C(lit.) |
Hazard statements
- H228Flammable solid
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 56 °C / 132.8 °F |
| Transport (UN / ADR) | UN 1325 4.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Ethylpiperidine hypophosphite used for?
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1-Ethylpiperidine hypophosphite is used as a reagent in organic synthesis for applications including the synthesis of spiroketals via intramolecular iodoetherification, radical cyclization reactions, radical deoxygenation, and the synthesis of allylic H-phosphinates.
What are the CAS number and formula for 1-Ethylpiperidine hypophosphite?
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The CAS number is 145060-63-5, and the empirical formula (Hill notation) is C7H18NO2P.
What grade and purity does Tech Serve Solutions supply for 1-Ethylpiperidine hypophosphite?
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Tech Serve Solutions supplies 1-Ethylpiperidine hypophosphite with an assay of 95%. This product is intended for research and chemical synthesis and is not represented as USP, BP, EP, or pharmaceutical grade.
How should 1-Ethylpiperidine hypophosphite be handled safely?
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Handling 1-Ethylpiperidine hypophosphite requires caution due to its hazards. It is flammable (H228), harmful if swallowed, in contact with skin, or if inhaled (H302, H312, H332), and causes skin and eye irritation (H315, H319) and may cause respiratory irritation (H335). Use appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Handle in a well-ventilated area and keep away from heat and ignition sources.
Is 1-Ethylpiperidine hypophosphite a controlled substance?
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Based on the provided data, there is no indication that 1-Ethylpiperidine hypophosphite is a controlled or scheduled substance.
How is 1-Ethylpiperidine hypophosphite packaged and shipped?
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1-Ethylpiperidine hypophosphite is packaged and shipped according to relevant regulations for hazardous materials, identified as UN 1325, Class 4.1, Packing Group II. It is typically stored at 2-8°C. Tech Serve Solutions exports chemicals globally.
How can I request a quote or sample for 1-Ethylpiperidine hypophosphite?
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To request a quote or a sample of 1-Ethylpiperidine hypophosphite, please contact our sales team through the TSS website or by phone. Our team will assist you with your inquiry and provide the necessary details.
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