(1-Ethoxycyclopropoxy)trimethylsilane
(1-Ethoxycyclopropoxy)trimethylsilane (CAS: 27374-25-0; Formula: C2H5OC3H4OSi(CH3)3; Molar Mass: 174.31 g/mol) is a valuable organic building block. This protected alcohol derivative serves as a key intermediate in complex organic synthesis. Its unique structure allows for controlled introduction of cyclopropane functionalities in various chemical transformations, making it indispensable for researchers and manufacturers in the fine chemical and pharmaceutical sectors.
- IUPAC
- Cyclopropanone ethyl trimethylsilyl acetal

Organic Synthesis Intermediate
Utilised as a versatile synthon for introducing protected cyclopropanone ethyl acetal moieties into organic molecules. Facilitates multi-step synthetic routes in the development of novel compounds.
Pharmaceutical Research and Development
Serves as a critical building block in the discovery and synthesis of new active pharmaceutical ingredients (APIs). Its application aids in creating complex molecular architectures required for therapeutic agents.
Fine Chemical Manufacturing
Employed in the production of specialised fine chemicals where precise control over functional group manipulation is required. Enables efficient synthesis of target molecules with high purity.
| Molecular weight | 174.31 |
|---|---|
| Linear formula | C2H5OC3H4OSi(CH3)3 |
| Assay | 99% |
| Boiling point | 50-53 °C/22 mmHg(lit.) |
| Density | 0.867 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.407(lit.) |


Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 26 °C / 78.8 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (1-Ethoxycyclopropoxy)trimethylsilane used for?
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(1-Ethoxycyclopropoxy)trimethylsilane is used as a versatile intermediate in organic synthesis, particularly for introducing protected cyclopropanone ethyl acetal groups into molecules during the development of fine chemicals and pharmaceuticals.
What is the CAS number and chemical formula for (1-Ethoxycyclopropoxy)trimethylsilane?
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The CAS number is 27374-25-0, and the chemical formula is C2H5OC3H4OSi(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies (1-Ethoxycyclopropoxy)trimethylsilane with an assay of 99%. This is a high-purity chemical suitable for research and synthesis; TSS does not represent it as USP, BP, or EP grade.
How should (1-Ethoxycyclopropoxy)trimethylsilane be handled safely?
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Handle with appropriate personal protective equipment, including eyeshields, gloves, and a respirator if necessary. This compound is flammable (flash point 26 °C) and may cause skin, eye, and respiratory irritation. Refer to the Safety Data Sheet for full handling procedures.
Is (1-Ethoxycyclopropoxy)trimethylsilane a controlled substance?
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Based on the provided data, (1-Ethoxycyclopropoxy)trimethylsilane is not listed as a controlled substance.
How are your chemicals packed and exported?
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Tech Serve Solutions exports chemicals globally, ensuring appropriate packaging standards are met for safe transit and compliance with international shipping regulations.
How can I request a quote or sample?
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To request a quote or sample of (1-Ethoxycyclopropoxy)trimethylsilane, please contact our sales team through the website or via direct inquiry.
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