1-Bromo-3,5-difluorobenzene
1-Bromo-3,5-difluorobenzene (CAS 461-96-1) is a fluorinated aryl building block with the linear formula BrC<sub>6</sub>H<sub>3</sub>F<sub>2</sub> and a molecular weight of 192.99 g/mol. This compound serves as a valuable intermediate in organic synthesis. It is primarily utilised in the development of novel organic compounds and pharmaceutical intermediates, offering a difluorinated phenyl ring for incorporation into complex molecular structures.
- Synonyms
- BrC6H3F2
Synthesis of Carboxylic Acids
1-Bromo-3,5-difluorobenzene has been employed as a precursor in the synthesis of substituted benzoic acids. An example includes its use in the preparation of 4-bromo-2,6-difluorobenzoic acid.
Fluorinated Organic Building Block
As a difluorinated aromatic compound, it functions as a versatile building block in medicinal chemistry and materials science. Its structure allows for the introduction of specific fluorine substitution patterns.
Research and Development
This compound is utilised in academic and industrial research laboratories for the exploration of new synthetic methodologies and the creation of novel chemical entities with potential applications.
| Molecular weight | 192.99 |
|---|---|
| Linear formula | BrC6H3F2 |
| Assay | 98% |
| Boiling point | 140 °C(lit.) |
| Density | 1.676 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.499(lit.) |
| Application | 1-Bromo-3,5-difluorobenzene was used in the synthesis of 4-bromo-2,6-difluorobenzoic acid1. |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H373May cause damage to organs through prolonged exposure
- H410Very toxic to aquatic life with long-lasting effects
Precautionary statements
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P501Dispose of contents and container per local regulations
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 44 °C / 111.2 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 10-22-38-43-48/22-50/53 |
| Safety statements (S) | 24-36/37-60-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Bromo-3,5-difluorobenzene used for?
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1-Bromo-3,5-difluorobenzene is used as a building block in organic synthesis, particularly for the preparation of fluorinated organic compounds and pharmaceutical intermediates. It has been used in the synthesis of substituted benzoic acids.
What is the CAS number and formula for 1-Bromo-3,5-difluorobenzene?
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The CAS number is 461-96-1, and its linear formula is BrC<sub>6</sub>H<sub>3</sub>F<sub>2</sub>.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Bromo-3,5-difluorobenzene with an assay of 98%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades unless explicitly stated.
What are the safety considerations for handling 1-Bromo-3,5-difluorobenzene?
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1-Bromo-3,5-difluorobenzene is a flammable liquid and vapour (H226), harmful if swallowed (H302), causes skin irritation (H315), may cause an allergic skin reaction (H317), may cause damage to organs through prolonged or repeated exposure (H373), and is very toxic to aquatic life with long-lasting effects (H410). Always handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, and avoid release to the environment.
How is 1-Bromo-3,5-difluorobenzene shipped?
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1-Bromo-3,5-difluorobenzene is shipped according to international regulations for hazardous materials, identified under UN 1993 (C3/PGIII).
How can I request a sample or quote for 1-Bromo-3,5-difluorobenzene?
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To request a sample or a quote for 1-Bromo-3,5-difluorobenzene, please contact our sales team via the website or your dedicated account manager.
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