1-Azido-3-iodobenzene solution
1-Azido-3-iodobenzene solution (CAS 54467-96-8, C6H4IN3) is a chemical reagent featuring an aryl azide and an iodine substituent. With a molecular weight of 245.02 g/mol, this compound is typically supplied as a solution of approximately 0.5 M in tert-butyl methyl ether. It serves as a versatile building block in organic synthesis, particularly for introducing the 3-iodophenyl moiety or participating in click chemistry reactions. Its reactive nature necessitates careful handling.
- IUPAC
- 3-Iodophenyl azide solution
- Synonyms
- 3-Iodophenyl azide solution
Organic Synthesis Building Block
1-Azido-3-iodobenzene solution is valuable for constructing complex organic molecules. The iodine atom allows for participation in various cross-coupling reactions, while the azide group can be used in click chemistry or reduced to an amine.
Click Chemistry Reagent
The azide functionality makes this compound suitable for copper-catalyzed or strain-promoted alkyne-azide cycloaddition (CuAAC or SPAAC) reactions, enabling the efficient formation of triazole linkages in bioconjugation and materials science.
Precursor for Amine Synthesis
Reduction of the azide group in 1-azido-3-iodobenzene yields 3-iodoaniline, a useful intermediate in the synthesis of pharmaceuticals and agrochemicals. This transformation can be achieved using various reducing agents.
| Molecular weight | 245.02 |
|---|---|
| Empirical formula | C6H4IN3 |
| Assay | ≥97.0% (HPLC) |
| Concentration | ~0.5 M in tert-butyl methyl ether |
| Storage temperature | −20°C |
| Impurities tested | ≤2.0% water |
Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H372Causes damage to organs through prolonged exposure
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P305IF IN EYES
- P314Get medical attention if you feel unwell
| Flash point | -33 °C / -27.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2398 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,T |
| Risk statements (R) | 11-38-48/23/24/25 |
| Safety statements (S) | 16 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Azido-3-iodobenzene solution used for?
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1-Azido-3-iodobenzene solution is used as a versatile building block in organic synthesis, particularly for click chemistry reactions and as a precursor for the synthesis of 3-iodoaniline.
What is the CAS number and formula for 1-Azido-3-iodobenzene solution?
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The CAS number is 54467-96-8 and the empirical formula is C6H4IN3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Azido-3-iodobenzene solution with an assay of ≥97.0% (HPLC). Impurities include ≤2.0% water. This is a technical grade and not represented as USP, BP, or EP.
How should 1-Azido-3-iodobenzene solution be handled safely?
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This compound is highly flammable (flash point -33 °C) and poses significant health risks, including potential long-term organ damage (H372). Handle with extreme caution in a well-ventilated area, away from ignition sources, using appropriate personal protective equipment (P210, P314).
How is 1-Azido-3-iodobenzene solution packed, shipped, and exported?
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1-Azido-3-iodobenzene solution is shipped as UN 2398, Hazard Class 3, Packing Group II. TSS exports fine chemicals globally, adhering to all necessary shipping and regulatory requirements.
How can I request a sample or quote for 1-Azido-3-iodobenzene solution?
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Please contact our sales team via the website or by phone to request a sample or obtain a quotation for 1-Azido-3-iodobenzene solution.
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