1-Adamantyl fluoroformate
1-Adamantyl fluoroformate (CAS: 62087-82-5; Formula: C11H15FO2; MW: 198.23) is a chemical reagent primarily used as an intermediate in organic synthesis. It serves as a valuable protecting group reagent, particularly for amines, due to the stability of the resulting adamantyloxycarbonyl (Adoc) group. This reagent finds application in complex molecule construction and peptide chemistry where selective amine protection is crucial for synthetic strategy.
Amine Protection
1-Adamantyl fluoroformate is employed to introduce the adamantyloxycarbonyl (Adoc) protecting group onto primary and secondary amines. The Adoc group offers distinct cleavage conditions compared to other common carbamate protecting groups, providing orthogonal protection strategies in multi-step syntheses.
Peptide Synthesis
In peptide chemistry, this reagent is utilised for the selective protection of amino groups within amino acids or peptide fragments. The Adoc group's stability under various conditions and its specific deprotection methods make it a useful tool for solid-phase and solution-phase peptide synthesis.
Organic Synthesis Intermediate
As a versatile building block, 1-Adamantyl fluoroformate participates in the synthesis of various organic compounds. Its reactivity allows for its incorporation into diverse molecular frameworks, facilitating the development of novel chemical entities.
| Molecular weight | 198.23 |
|---|---|
| Empirical formula | C11H15FO2 |
| Assay | ≥90% |
| Grade | technical |
| Storage temperature | 2-8°C |
| Melting point | 30-32 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | 88 °C / 190.4 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Adamantyl fluoroformate used for?
+
1-Adamantyl fluoroformate is primarily used as a reagent for introducing the adamantyloxycarbonyl (Adoc) protecting group onto amines, particularly in organic synthesis and peptide chemistry.
What is the CAS number and formula for 1-Adamantyl fluoroformate?
+
The CAS number is 62087-82-5, and the empirical formula is C11H15FO2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 1-Adamantyl fluoroformate in a technical grade with an assay of ≥90%. We do not represent this product as USP, BP, or EP grade.
How should 1-Adamantyl fluoroformate be handled safely?
+
1-Adamantyl fluoroformate is a Danger hazard (H314), causing severe skin burns and eye damage. Handle with appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection. Ensure adequate ventilation and refer to the Safety Data Sheet for detailed handling procedures.
Is 1-Adamantyl fluoroformate a controlled substance?
+
The provided data does not indicate that 1-Adamantyl fluoroformate is a controlled substance.
How is 1-Adamantyl fluoroformate packed and shipped?
+
This product is typically packed and shipped according to UN 3261 8 / PGII regulations, indicating it is a corrosive solid, acidic, organic, n.o.s. Specialised export procedures are followed by TSS.
How can I request a sample or quote for 1-Adamantyl fluoroformate?
+
Please contact our sales team via the website or direct email to request a sample or obtain a quotation for 1-Adamantyl fluoroformate.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis