1,4,7-Tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane
1,4,7-Tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane (CAS: 247193-74-4) is a protected cyclen derivative with the empirical formula C25H46N4O8 and a molecular weight of 530.65 g/mol. This compound serves as a key building block in organic synthesis, enabling the attachment of the cyclen macrocycle to various molecular scaffolds. It is valuable for research in supramolecular chemistry and the development of novel chelating agents and functionalised molecules.
- IUPAC
- (4,7,10-Tri-Boc-1,4,7,10-tetraazacyclodecan-1-yl)acetic acid
- Synonyms
- (4,7,10-Tri-Boc-1,4,7,10-tetraazacyclodecan-1-yl)acetic acid4,7,10-tetraazacyclododecane,247193-74-4, C25H46N4O8
Molecular Scaffold Attachment
This compound is utilised as a building block for conjugating the cyclen macrocycle to larger molecular structures. Its protected nature allows for controlled functionalisation and integration into complex molecular designs.
Research in Medicinal Chemistry
It has been employed in studies exploring selective RNA cleavage, such as the targeted disruption of the HIV-1 TAR-RNA with peptide-cyclen conjugates. This highlights its potential in developing novel therapeutic agents.
Chelation and Complexation Studies
As a derivative of cyclen, it is relevant for research in coordination chemistry and the development of metal ion chelators. The protected functional groups allow for tailored synthesis of complexation agents.
| Molecular weight | 530.65 |
|---|---|
| Empirical formula | C25H46N4O8 |
| Assay | ≥97.5% (TLC)98% (TLC) |
| Storage temperature | 2-8°C |
| Application | Building block used to attach the Cyclen azacrown to a molecular scaffold1; selective cleavage of the HIV-1 TAR-RNA with a peptide-cyclen conjugate2 |
| Melting point | 137-142 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,4,7-Tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane used for?
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It is primarily used as a building block to attach the cyclen macrocycle to molecular scaffolds and in research involving selective RNA cleavage, such as with peptide-cyclen conjugates.
What are the CAS number and formula for this compound?
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The CAS number is 247193-74-4, and the empirical formula is C25H46N4O8.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this compound with an assay of ≥97.5% (TLC) or 98% (TLC). TSS does not represent this product as meeting USP, BP, EP, or any other pharmacopoeia standards.
How should 1,4,7-Tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane be handled and stored?
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It is a Warning substance, classified with H315, H319, and H335 hazards, indicating skin, eye, and respiratory irritation. Handle with a dust mask (N95), eyeshields, and gloves. Store at 2-8°C.
Is this product available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals.
How can I request a sample or quote?
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Please contact our sales team directly through our website or by phone to request a sample or a quotation for this product.
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