1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide methiodide
1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide methiodide (CAS 22572-40-3), with the molecular formula C2H5N=C=N(CH2)3N(CH3)3I and a molecular weight of 297.18, is a carbodiimide reagent. It functions primarily as a crosslinking agent and is a key reactant in amide bond forming reactions. This compound is widely utilized in chemical synthesis, peptide chemistry, and biochemical applications for coupling and amidation processes.
- IUPAC
- EDC methiodide
- Synonyms
- EDC methiodide
![1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide methiodide (C2H5N=C=N(CH2)3N(CH3)3I) — chemical structure, CAS 22572-40-3; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F22572-40-3.png&w=3840&q=75)
Amide Bond Formation
This carbodiimide is a highly effective reagent for promoting the formation of amide bonds. It activates carboxylic acids for nucleophilic attack by amines, facilitating crosslinking reactions crucial in peptide synthesis and bioconjugation.
Crosslinking Agent
As a crosslinking agent, 1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide methiodide can link molecules together, particularly biomolecules, by forming stable amide linkages. This is valuable in biochemical research and the modification of proteins and peptides.
Peptide Chemistry
In peptide chemistry, this compound serves as a coupling reagent to facilitate the formation of peptide bonds between amino acids. Its use aids in the synthesis of peptides and peptidomimetics.
Chemical Synthesis
Beyond peptide synthesis, it is a versatile reagent in general organic synthesis for creating amide linkages, enabling the construction of complex molecules and functionalised materials.
| Molecular weight | 297.18 |
|---|---|
| Linear formula | C2H5N=C=N(CH2)3N(CH3)3I |
| Storage temperature | 2-8°C |
| Application | • Crosslinking agent1Reactant for:• Amide bond forming (amidation) crosslinking reactions2,3 |
| Melting point | 97-99 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide methiodide used for?
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1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide methiodide (CAS 22572-40-3) is used as a crosslinking agent and a reactant for amide bond forming (amidation) crosslinking reactions, notably in peptide chemistry and general chemical synthesis.
What is the CAS number and formula for 1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide methiodide?
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The CAS number is 22572-40-3 and the linear formula is C2H5N=C=N(CH2)3N(CH3)3I.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and laboratory use. The specific assay and purity are detailed in our product specifications. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the specification sheet.
What are the safety and handling precautions for this chemical?
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This compound is classified as harmful if swallowed, in contact with skin, or if inhaled, and causes skin irritation, serious eye irritation, and may cause respiratory irritation (H302 + H312 + H332, H315, H319, H335). It requires the use of a dust mask type N95, eyeshields, and gloves. Handle in a well-ventilated area and avoid breathing dust.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions packs chemicals in compliance with international shipping regulations to ensure safe transit. We are experienced global exporters and can fulfil orders worldwide.
How can I request a sample or quote?
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To request a sample or a quote for 1-[3-(Dimethylamino)propyl]-3-ethylcarbodiimide methiodide, please contact our sales department via the website or by telephone. Our team will be pleased to assist you.
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