1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride

CAS 141556-45-8C21H25ClN2Catalysis & Inorganic

1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride (CAS: 141556-45-8; C21H25ClN2) is a key organometallic compound, widely recognised as an N-heterocyclic carbene (NHC) precursor. Its robust structure makes it valuable in homogeneous catalysis. This compound serves as a precursor to highly active carbene ligands, facilitating a range of organic transformations. It is a critical reagent in academic research and industrial synthesis for developing new catalytic processes.

IUPAC: 1,3-Bis(mesityl)imidazolium chloride,1,3-Dihydro-1,3-dimesityl-2H-imidazol-2-ylidene monohydrochloride,1,3-Dimesitylimidazolium chloride
Synonyms: 1,3-Bis(mesityl)imidazolium chloride1,3-Dimesitylimidazolium chloride1,3-Dihydro-1,3-dimesityl-2H-imidazol-2-ylidene monohydrochloride

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1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride (C21H25ClN2) — chemical structure, CAS 141556-45-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Carbon-Donor LigandsChemical SynthesisNHC Compounds

01 /Applications

Precursor for N-Heterocyclic Carbene (NHC) Ligands

This compound is a stable salt that readily deprotonates to form a highly reactive N-heterocyclic carbene. These carbenes are excellent ligands for transition metals, forming stable and active catalysts.

Homogeneous Catalysis

As an NHC precursor, it enables the development of catalysts for various organic reactions, including cross-coupling, metathesis, and C-H activation. The steric bulk of the mesityl groups influences catalyst stability and selectivity.

Organometallic Chemistry Research

It serves as a fundamental building block in the study of organometallic complexes and their reactivity. Researchers utilise it to synthesise novel metal-carbene complexes with tailored electronic and steric properties.

Chemical Synthesis

Its utility extends to facilitating challenging synthetic transformations in fine chemical and pharmaceutical intermediate production. The resulting catalysts can offer unique reactivity profiles compared to traditional phosphine ligands.

02 /Properties

Molecular weight	340.89
Empirical formula	C21H25ClN2
Melting point	>300 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

141556-45-8

MDL number

MFCD02684541

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride used for?

This compound is primarily used as a precursor for generating N-heterocyclic carbene (NHC) ligands, which are crucial in homogeneous catalysis for various organic transformations, including cross-coupling and metathesis reactions.

What is the CAS number and formula for this chemical?

The CAS number is 141556-45-8, and the empirical formula is C21H25ClN2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical as a research-grade material. While specific assay details are available on the Certificate of Analysis, we do not represent this product as meeting USP, BP, or EP pharmacopoeia standards.

How should 1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride be handled?

This compound is classified as a warning substance and may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves, in a well-ventilated area. Avoid breathing dust.

Is this product suitable for export?

Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, including 1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride. We adhere to international shipping regulations.

How can I request a sample or quote?

To request a sample or a detailed quote, please contact our sales department via the 'Request a Quote' or 'Sample Request' forms on our website, or call us directly. Please reference the product name and CAS number.