1-(3-Aminopropyl)imidazole
1-(3-Aminopropyl)imidazole (CAS 5036-48-6) is a difunctional heterocyclic building block combining an imidazole ring with a pendant primary amine on a three-carbon chain. With molecular formula C6H11N3 and a molar mass of 125.17 g/mol, it is a liquid (density 1.049 g/mL at 25 °C) supplied at ≥97% assay. Its dual reactivity makes it valuable in chemical synthesis, polymer modification and the preparation of pH-sensitive materials. Tech Serve Solutions supplies it for research and industrial applications worldwide.
- Synonyms
- 1-(3-Aminopropyl)imidazole3-(1H-Imidazol-1-yl)propan-1-amine1-(3-Aminopropyl)-1H-imidazoleN-(3-Aminopropyl)imidazole3-Imidazol-1-ylpropylamine1-(3-Aminopropyl)imidazole CAS 5036-48-6
Heterocyclic building block
Serves as a versatile C3-amine-functionalised imidazole intermediate in chemical synthesis. The combination of a basic imidazole nitrogen and a reactive primary amine allows it to be incorporated into more complex molecules and ligand frameworks.
pH-sensitive polymer synthesis
Reported in the synthesis of pH-sensitive polyaspartamide derivatives, where the imidazole group imparts responsiveness to changes in pH. This supports the design of stimuli-responsive polymeric materials.
Amphiphilic polymer modification
Used in the preparation of pH-sensitive amphiphilic polymers bearing octadecylamine (C18) substituents introduced by graft reaction. The pendant amine provides a convenient handle for grafting hydrophobic chains.
Amine functionalisation and conjugation
The primary amine readily forms amides, imines and related linkages, making the compound useful as a coupling partner for introducing an imidazole moiety onto carboxylic acids, polymers and surfaces in research settings.
Coordination chemistry
The imidazole nitrogen is a recognised donor for metal coordination, allowing this reagent to be used in the exploratory preparation of metal complexes and functional ligands.
| Molecular weight | 125.17 |
|---|---|
| Empirical formula | C6H11N3 |
| Assay | ≥97% |
| Density | 1.049 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.519(lit.) |
| Application | 1-(3-Aminopropyl)imidazole was used in the synthesis of pH-sensitive polyaspartamide derivatives1. It was also used in the preparation of pH-sensitive amphiphilic polymers with different degrees of octaceylamine (C18) substitution by graft reaction2. |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3267 8 / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(3-Aminopropyl)imidazole used for?
+
It is mainly used as a heterocyclic building block in chemical synthesis. Documented uses include the synthesis of pH-sensitive polyaspartamide derivatives and the preparation of pH-sensitive amphiphilic polymers with octadecylamine (C18) substitution by graft reaction. Its primary amine and imidazole ring also make it useful for amine functionalisation and coordination chemistry.
What is the CAS number and molecular formula of 1-(3-Aminopropyl)imidazole?
+
The CAS number is 5036-48-6 and the molecular formula is C6H11N3 (Hill notation), with a molecular weight of 125.17 g/mol. Related identifiers include EC number 225-730-9 and MDL number MFCD00009819.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 1-(3-Aminopropyl)imidazole at a typical assay of ≥97% as a research and technical grade material. We do not represent it as USP, BP or EP pharmacopoeia grade. A Certificate of Analysis is provided with each batch and specifications can be confirmed against your requirements on request.
Is 1-(3-Aminopropyl)imidazole hazardous, and how should it be handled?
+
Yes. It is classified GHS05 with the signal word Danger and hazard statement H314 — it causes severe skin burns and eye damage. Handle it with suitable gloves, goggles or a face shield and respiratory protection, avoiding all skin and eye contact (precautionary statements P280, P305+P351+P338, P310). Always consult the Safety Data Sheet before use.
How is 1-(3-Aminopropyl)imidazole packed, shipped and exported?
+
It is supplied in securely sealed containers appropriate to the order quantity, each labelled with batch and hazard information. As a corrosive liquid it is classified for transport as UN 3267, Class 8, Packing Group II, and is shipped in compliant packaging with full documentation. Tech Serve Solutions exports worldwide by road, sea and air through established freight channels.
How do I request a sample or quote?
+
Contact Tech Serve Solutions with your required quantity, purity and delivery destination, and our team will respond with availability, lead time and documentation. Samples can be arranged where appropriate. We support both research-scale and bulk commercial requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis