1,3,5-Trifluorobenzene
1,3,5-Trifluorobenzene (CAS 372-38-3) is a fluorinated aromatic compound with the molecular formula C6H3F3 and a molecular weight of 132.08 g/mol. It presents as a liquid and serves as a valuable building block in organic synthesis. Its applications primarily lie in the development of complex organic molecules, particularly within pharmaceutical research and chemical synthesis, leveraging the unique properties imparted by its trifluorinated benzene structure.
- Synonyms
- 372-38-3C6H3F3
Synthesis of Pharmaceutical Intermediates
1,3,5-Trifluorobenzene acts as a key precursor in the synthesis of advanced organic molecules. It has been utilised in the preparation of compounds such as (−)-epicatechin and its derivatives, which may be relevant for further pharmaceutical development.
Organic Building Block
As a fluorinated aryl building block, this compound offers unique reactivity for introducing trifluorinated phenyl moieties into larger molecular structures. This is beneficial in medicinal chemistry and materials science research.
Chemical Research and Development
The compound is employed in laboratory settings for various chemical synthesis studies. Its defined structure and properties make it a reliable reagent for exploring new synthetic pathways and developing novel compounds.
| Molecular weight | 132.08 |
|---|---|
| Empirical formula | C6H3F3 |
| Assay | 97% |
| Boiling point | 75-76 °C(lit.) |
| Density | 1.277 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.414(lit.) |
| Application | 1,3,5-Trifluorobenzene was used in the synthesis of (−)-epicatechin and its 3-O-gallate1. |
| Melting point | −5.5 °C(lit.) |
Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | -7 °C / 19.4 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,3,5-Trifluorobenzene used for?
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1,3,5-Trifluorobenzene is used as a building block in organic synthesis, notably in the preparation of compounds like (−)-epicatechin and its gallate. It is a key reagent in chemical research and development for introducing trifluorinated phenyl groups into target molecules.
What are the CAS number and molecular formula for 1,3,5-Trifluorobenzene?
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The CAS number for 1,3,5-Trifluorobenzene is 372-38-3, and its molecular formula is C6H3F3.
What grade and purity does Tech Serve Solutions supply for 1,3,5-Trifluorobenzene?
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Tech Serve Solutions supplies 1,3,5-Trifluorobenzene with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
How should 1,3,5-Trifluorobenzene be handled safely?
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1,3,5-Trifluorobenzene is a flammable liquid and vapour (H225), causing skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, in a well-ventilated area away from ignition sources.
Is 1,3,5-Trifluorobenzene a controlled substance?
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The provided data does not indicate that 1,3,5-Trifluorobenzene is a controlled substance.
How is 1,3,5-Trifluorobenzene packed, shipped, and exported?
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1,3,5-Trifluorobenzene is packed and shipped according to international regulations for hazardous materials, including UN 1993 BF 3 / PGII classification. Tech Serve Solutions has extensive experience in exporting chemicals globally.
How can I request a quote or sample of 1,3,5-Trifluorobenzene?
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To request a quote or sample, please contact our sales team through the website or by phone, providing your specific requirements.
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