1-(2-Methylbenzyl)piperazine
1-(2-Methylbenzyl)piperazine (CAS 5321-47-1) is a substituted piperazine building block with the molecular formula C12H18N2 and a molar mass of 190.28 g/mol. It pairs a piperazine ring with an ortho-methylbenzyl group, giving a versatile secondary amine for chemical synthesis. Tech Serve Solutions supplies it as a research-grade reagent (97% assay) for use as a heterocyclic intermediate in pharmaceutical and fine-chemical discovery, ligand preparation and structure-activity studies.
- Synonyms
- 1-(2-Methylbenzyl)piperazine1-(2-methylbenzyl)piperazine2-methylbenzylpiperazine1-(2-methylphenylmethyl)piperazine1-[(2-methylphenyl)methyl]piperazineo-methylbenzylpiperazine
Pharmaceutical intermediate
Serves as a piperazine building block in the synthesis of drug-discovery candidates and active-ingredient scaffolds. The free secondary nitrogen offers a convenient site for acylation, alkylation and reductive amination.
Heterocyclic building block
Used in chemical synthesis to introduce a 2-methylbenzyl-substituted piperazine motif into larger molecules. The ortho-methyl substitution allows medicinal chemists to explore steric and electronic effects on candidate structures.
Ligand and coordination chemistry
The diamine architecture can act as a ligand or ligand precursor in coordination and catalysis research. It is typically employed on a laboratory or process-development scale rather than in bulk applications.
Research and analytical reference
Suited to method development, structure-activity relationship work and reference characterisation in academic and industrial laboratories, supported by defined physical constants such as refractive index and density.
| Molecular weight | 190.28 |
|---|---|
| Empirical formula | C12H18N2 |
| Assay | 97% |
| Boiling point | 77-80 °C/0.1 mmHg(lit.) |
| Density | 0.998 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5430(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(2-Methylbenzyl)piperazine used for?
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It is used mainly as a piperazine building block and heterocyclic intermediate in chemical synthesis. Chemists incorporate it into pharmaceutical discovery scaffolds, ligands and structure-activity studies, exploiting its reactive secondary amine for further functionalisation.
What is the CAS number and molecular formula of 1-(2-Methylbenzyl)piperazine?
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The CAS number is 5321-47-1 and the molecular formula is C12H18N2, with a molecular weight of 190.28 g/mol. Its MDL number is MFCD02256026 and its EC number is 226-183-9.
What grade and purity does Tech Serve Solutions supply?
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We supply 1-(2-Methylbenzyl)piperazine as a research/technical-grade reagent with a typical assay of 97%. It is not represented as USP, BP or EP pharmacopoeial grade. A certificate of analysis is provided with each batch, and indicative physical data include a refractive index of n20/D 1.5430 and a density of 0.998 g/mL at 25 °C.
What are the safety and handling requirements for 1-(2-Methylbenzyl)piperazine?
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It carries GHS pictogram GHS07 with the signal word Warning. The hazard statements are H302 (harmful if swallowed), H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye and face protection and adequate ventilation; in case of eye contact, rinse cautiously with water for several minutes. It is classified WGK 2 (water-hazard class). Always consult the Safety Data Sheet before use.
How is 1-(2-Methylbenzyl)piperazine packed, shipped and exported?
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It is packed in tightly sealed, appropriately labelled containers sized to your order, from laboratory quantities to bulk. Shipments are prepared with full documentation, including a certificate of analysis and Safety Data Sheet, and exported worldwide in line with applicable dangerous-goods and customs requirements.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packing and destination, quoting the product name and CAS 5321-47-1. Our team will respond with availability, lead time, documentation and a formal quotation.
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