1,2-Dimethylindole
1,2-Dimethylindole (CAS: 875-79-6) is a versatile heterocyclic organic compound with the molecular formula C10H11N and a molecular weight of 145.20 g/mol. Possessing the characteristic indole structure, this chemical serves as a valuable building block in complex organic synthesis. Its applications span the preparation of functionalised indoles, carbazoles, and trifluoromethylindoles, demonstrating its utility in the development of novel chemical entities.
- IUPAC
- NSC 62087
- Synonyms
- 1,2-Dimethylindole1,2-Dimethyl-1H-indole
Preparation of 3-Functionalised Indoles
1,2-Dimethylindole acts as a key starting material for the synthesis of various 3-substituted indole derivatives, which are prevalent motifs in medicinal chemistry and materials science.
Synthesis of Carbazoles
This compound is employed as a precursor in the construction of carbazole ring systems, known for their applications in organic electronics and as pharmaceutical scaffolds.
Creation of Cyanoindoles
The indole nucleus of 1,2-Dimethylindole can be functionalised to introduce cyano groups, yielding cyanoindole intermediates useful in further synthetic transformations.
Preparation of Trifluoromethylindoles
It serves as a reactant for introducing trifluoromethyl groups onto the indole framework, leading to compounds with altered electronic properties and potential biological activity.
Antihyperlipidemic Agents
1,2-Dimethylindole is a building block used in the synthesis of potent antihyperlipidemic agents, contributing to the development of cardiovascular therapeutics.
Nazarov and Iso-Nazarov Cyclizations
The compound participates in Nazarov and iso-Nazarov cyclization reactions, enabling the formation of complex polycyclic systems.
| Molecular weight | 145.20 |
|---|---|
| Empirical formula | C10H11N |
| Assay | 99% |
| Application | • Building block for preparation of 3-functionalized indoles1• Building block for preparation carbazoles2• Building block for preparation of cyanoindoles3• Reactant for preparation of trifluoromethylindoles4• Reactant for preparation of potent antihyperlipidemic agents5• Building block in iso-Nazarov or Nazarov cyclizations6• Reactant for preparation of GSK-3 |
| Melting point | 55-58 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,2-Dimethylindole used for?
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1,2-Dimethylindole (CAS: 875-79-6) is primarily used as a building block in organic synthesis. It is instrumental in the preparation of 3-functionalized indoles, carbazoles, cyanoindoles, trifluoromethylindoles, and antihyperlipidemic agents. It also finds application in iso-Nazarov or Nazarov cyclizations.
What are the CAS number and chemical formula for 1,2-Dimethylindole?
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The CAS number for 1,2-Dimethylindole is 875-79-6, and its empirical formula is C10H11N.
What grade and purity does Tech Serve Solutions supply for 1,2-Dimethylindole?
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Tech Serve Solutions supplies 1,2-Dimethylindole with a minimum purity of 99% (Assay: 99%). This product is supplied for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
What are the primary safety considerations when handling 1,2-Dimethylindole?
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1,2-Dimethylindole is combustible and has a flash point of 113 °C (235.4 °F). When handling, it is essential to use personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. Refer to the Safety Data Sheet (SDS) for comprehensive handling and hazard information.
How is 1,2-Dimethylindole packed, shipped, and exported by TSS?
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1,2-Dimethylindole is carefully packed to ensure integrity during transit. Tech Serve Solutions, established in 1998, is a specialist global supplier and exporter of fine chemicals, adhering to all relevant shipping and export regulations.
How can I request a sample or obtain a quote for 1,2-Dimethylindole?
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To request a sample or obtain a quote for 1,2-Dimethylindole, please use the 'Request Sample' or 'Get Quote' button on our product page, or contact our sales department directly.
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