1,2,4-Butanetricarboxylic acid
1,2,4-Butanetricarboxylic acid (CAS: 923-42-2) is a tricarboxylic acid with the molecular formula C7H10O6 and a molecular weight of 190.15 g/mol. This organic compound serves as a valuable building block in chemical synthesis. Its structure allows for interaction with metal ions, notably its role in the tetracoordinate Ni(II) binding by E. coli NikA. It is also explored for its potential as an inhibitor of glutamate carboxypeptidase II, indicating diverse biological and research applications.
- IUPAC
- 1,2,4-Tricarboxybutane,3-Carboxyhexanedioic acid,NSC 60127,NSC 8447
- Synonyms
- 923-42-2HO2CCH2CH2CH(CO2H)CH2CO2H1,2,4-Tricarboxybutane3-Carboxyhexanedioic acidNSC 60127NSC 8447
Biochemical Research
1,2,4-Butanetricarboxylic acid is utilised in biochemical studies, particularly in understanding metal ion binding mechanisms. Its interaction with E. coli NikA, involving His416 and carboxylate ligands, is a key area of investigation.
Enzyme Inhibition Studies
The compound shows potential as an inhibitor for enzymes like glutamate carboxypeptidase II. This application is relevant for research in pharmacology and cell biology, exploring new therapeutic avenues.
Organic Synthesis Building Block
As a multifunctional carboxylic acid, 1,2,4-Butanetricarboxylic acid serves as a versatile building block in organic synthesis. Its reactive carboxyl groups can be modified for the construction of more complex molecules.
| Molecular weight | 190.15 |
|---|---|
| Linear formula | HO2CCH2CH2CH(CO2H)CH2CO2H |
| Application | Biological activity:• Tetracoordinate Ni(II) binding by E. coli NikA employs His416 residue in conjunction with three carboxylate ligands from butane-1,2,4-tricarboxylate (BTC)1• Potential inhibitor of glutamate carboxypeptidase II2 |
| Melting point | 117-120 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... FOLH1(2346) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,2,4-Butanetricarboxylic acid used for?
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1,2,4-Butanetricarboxylic acid is used in biochemical research, particularly for studying metal ion binding, and shows potential as an enzyme inhibitor for targets like glutamate carboxypeptidase II. It also functions as a building block in organic synthesis.
What is the CAS number and molecular formula for 1,2,4-Butanetricarboxylic acid?
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The CAS number for 1,2,4-Butanetricarboxylic acid is 923-42-2, and its molecular formula is C7H10O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,2,4-Butanetricarboxylic acid as a research chemical. The specific assay is not detailed beyond its intended use for laboratory and research purposes. TSS does not represent this product as USP, BP, or EP grade.
How should 1,2,4-Butanetricarboxylic acid be handled safely?
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Based on GHS classifications, 1,2,4-Butanetricarboxylic acid is a Warning substance (H315, H319, H335). Handle with appropriate personal protective equipment, including a dust mask (type N95 or equivalent), eyeshields, and gloves. Ensure adequate ventilation and avoid inhalation of dust, skin, and eye contact.
Is 1,2,4-Butanetricarboxylic acid available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 1,2,4-Butanetricarboxylic acid, and can accommodate international orders.
How can I request a sample or quote for 1,2,4-Butanetricarboxylic acid?
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To request a sample or a quote for 1,2,4-Butanetricarboxylic acid, please contact our sales team through the website or by calling our office. Provide your specific requirements, and we will respond promptly.
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